Episode 1
New trainee doctor Lily jumps straight in to investigate a disastrous robbery on the open road, while Dixie builds a bond with a game old bird to help her carry out a romantic mission.
Episode 2
Nurse Rita is late for her first shift as she contends with an injured neighbour whose hoarding has got out of control, while Jamie bonds with a failed asylum seeker too scared to tell the authorities he's gay.
Episode 3
Jamie almost brings the whole ED to a standstill as he becomes embroiled in attempts to assist an Iranian immigrant, meanwhile Sam's maternal skills are revealed as she rescues the baby of a broken family.
Episode 4
Ash and Jeff are forced to dive into the sea to save a teenager who's been tombstoning, while Fletch and Rita treat a boy who is claiming to be the reincarnation of an elderly lady's brother.
Episode 5
Lily is assigned to an emotional case involving a teenage cancer patient in order to learn some empathy, while Charlie investigates an act of heroism as a bus crash unravels a web of deceit.
Episode 6
Treating two brothers who come to blows with a drug dealer tests Iain and Jeff's ability to get on, while Jamie susses out that a patient is faking it to get his mother's attention.
Episode 7
Rita and Ash look after a young girl who is keeping secrets from her charming boyfriend, and Fletch is worried about two sisters who are struggling to look after each other as they get older.
Episode 8
Iain helps a teenager caught up in a fatal car crash to face up to the truth, while Fletch decides to shoulder the blame for Tess's mistake.
Episode 9
Tess has to confront her own problems when a pregnant woman is involved in a road traffic collision, and Robyn and Jamie witness the effects of a batch of bad pills on the Holby nightlife.
Episode 10
Ash and Tess work to discover why a mother and daughter are so at odds about how far the team should go to save the father's life, while Jamie accidentally helps crack open a love triangle.
Episode 11
Rita's day with the paramedics brings her close to a patient in a serious entrapment, and Big Mac is able to make a real difference with a destitute man.
Episode 12
Jeff helps a father and his sons after they get into trouble over a hidden bag of cash. Sam treats a bride, not knowing that Tom intends to propose.
Episode 13
Iain is deeply affected by two police officers who stir up his memories of army life and Charlie tries to help a young family keep hold of their little girl.
Episode 14
Lily suspects steroids are to blame for a violent dispute between rugby players while Sam and new porter Max help a policeman in pursuit of the truth.
Episode 15
The pressure is on Fletch who's trying to balance responsibility with helping a vulnerable boy and Jamie unwittingly gives Lily a lesson in patient care.
Episode 16
Episode 17
Fletch has to rescue a child from danger when two brothers are involved in an accident, and Sam realises the truth about her own relationship when she re-starts the heart of a patient.
Episode 18
A young couple are forced to take refuge at a farm for the birth of their baby, while a man is electrocuted by a Christmas tree, disrupting Sam and Tom's wedding plans and causing Fletch to be arrested.
Episode 19
An explosion in a bar leads to a disastrous New Year's Eve for Fletch, and Robyn helps a silent singer find his voice.
Episode 20
Lily and new doctor Ethan diagnose teacher Alice with a rare disease, while Zoe and Tess fight to save the life of Dixie's girlfriend.
Episode 21
New doctor Cal goes to the rescue of a girl in a limo hanging precariously off a bridge, while his brother Ethan uncovers the truth about an art student whose sight is endangered by flying glass.
Episode 22
Dixie's accused of assault after a man she and Rita think is a rapist trips and hits his head. Ethan and Cal strive to help a little boy get his voice back.
Episode 23
Rita helps a rape victim gain the courage to press charges, while Zoe treats an eccentric ex-Tiller girl who must tell the truth about the daughter she put up for adoption.
Episode 24
On his last day at the ED, Jamie helps Cal and Ethan uncover abuse between a stepfather and his family while Dixie and Jeff help extract a man sinking in mud.
Episode 25
Iain defies orders and runs into a burning building to save a man searching for his new fiancee, while Lily steps into the breach as a magician's assistant when pensioner Yvonne gets injured.
Episode 26
Fletch's daughter runs away from home and lands herself in danger, while Robyn has to discover why a teenage girl is lying.
Episode 27
Lily makes a special connection with a new mother with learning disabilities. Robyn is intrigued when she discovers mysterious intruder Lofty hiding in her house, but is he really as kind and friendly as he appears?
Episode 28
Iain tries to help a distressed ex-army friend and his wife, while Lofty's keen eye helps save a young man who must learn to stand up to his brother.
Episode 29
Big Mac and Iain are held hostage by an angry ex-soldier, while Charlie must learn the identity of a patient so the team can race to save her son.
Episode 30
Ethan's conscience is tested when an activist asks him to hide his secrets, while Rita and Zoe help a desperate prisoner repair his relationship with his mother.
Episode 31
New consultant Connie Beauchamp saves a man from prison on her first day at the ED, while Ash takes his wayward daughter in hand.
Episode 32
Connie, Zoe and Lily pull together to treat a father and his daughter, who has ADHD, while Charlie helps an old biker come to terms with his wife's dementia.
Episode 33
Jeff, Rita and Lily help a morbidly obese man access the help he needs while Dixie bonds with an angry young motorcyclist.
Episode 34
Fletch builds bridges between a father and son estranged by drugs. Cal tries to discover what is wrong with a man who thinks he has a brain tumour.
Episode 35
Dixie risks her job to take a patient to see his dying mother, while another patient's unusual birthday treat to herself goes awry when she sniffs cocaine.
Episode 36
Dixie is given three months suspension by the Ambulance Trust and Connie makes Zoe question whether there was another procedure she could have tried in order to save a patient's life.
Episode 37
Ash realises the truth about his daughter when a patient's experience with drugs turns sour, while Fletch fights to repair a broken family on a couple's wedding day.
Episode 38
Cal tries to help a family torn apart by sibling rivalry, while Tess tries to help a pregnant teenager stand up to her controlling father.
Episode 39
Connie tries to help a father come to terms with his son's sexuality, while Cal helps treat a severely paranoid patient.
Episode 40
Rita finds herself in a difficult situation when a fire breaks out in an elderly care home, while Lily helps a man with toothache realise the true extent of his problem.
Episode 41
The ED struggle with increasing numbers, Connie fights to save a man with dementia, and Ethan and Rita work to convince a bulimic teenager that she needs help.
Episode 42
Zoe sticks up for the ED when the press turn up, but a horrific helicopter accident is the last straw that pushes her to make a difficult decision.
Episode 43
Tess is involved in a horrendous crash and Fletch sacrifices everything to save her.
Episode 44
A cross-country obstacle race accident brings together a father and son as well as Jeff and his new love interest.
Episode 45
Connie helps an ill man tell his wife the truth, and a leukaemia survivor comes to realise that she isn't ready for a family yet.
Episode 46
Rita receives a visit from her past which jeopardises her future, and Lofty and Cal bring a family back together with a bit of creative thinking.
Episode 47
Cal and Ethan work together to solve a medical mystery, while Rita helps a patient come to terms with a secret.
Episode 48
Zoe feels dissatisfied with life as she turns forty, while Cal steals Ethan's proposal idea but is exposed with some help from Lily.
