Episode 1
Zoe's first day as the ED'S clinical lead gets off to a trying start when the team are faced with dealing with the aftermath of a tunnel collapse at a music festival.
Episode 2
Tamsin faces a ghost from her past when she and Jeff attend a call out at a lap dancing club. Sam attempts to unravel the mystery of a patient with amnesia.
Episode 3
Sam and Tom are pushed to their limits when a female cage fighter insists on fighting against their advice, and a wedding is threatened to be ruined by devastating news.
Episode 4
Dylan and Tess must treat an agitated pregnant woman, while Fletch tries to unravel the relationship between a teenage girl and her swimming coach.
Episode 5
The team is put to the test when Holby is hit by severe weather, and the stress of work and dealing with a face from the past leads Big Mac's health to take a dangerous turn.
Episode 6
Medical drama. Fletch plays a practical joke on Lloyd after a staff night out, and Dylan attempts to teach a medical student about the dangers of alcohol abuse.
Episode 7
The team deal with an accident at a troubled small business, and a young businessman with heart problems is demanding staff find his missing phone
Episode 8
Zoe oversteps the line when she attempts to help a vulnerable young woman, and Mac gets into serious trouble on his first day back when a patient with Alzheimer's appears to have swallowed some cleaning fluid.
Episode 9
Zoe struggles to deal with the fallout of a suspected E. coli outbreak, and Dylan is touched by an elderly patient who has lost his beloved wife.
Episode 10
Zoe and the ED reap the fallout from the E-coli outbreak and things go from bad to worse for farmer Rob.
Episode 11
Dylan deals with a woman whose pregnancy is not all it seems, and teenager Angel is desperate to get some cash together to pay off her bullies.
Episode 12
Tamzin's decision not to treat an aggressive patient has serious repercussions, and Tom and Sam differ over how to approach a family with a dark secret.
Episode 13
A family are shocked to find out an intruder isn't all he seems to be, and a woman finds out she's the heir to her nasty aunt's fortune.
Episode 14
As Charlie and Big Mac prepare for the ED party, Dylan's suspicions reach boiling point.
Episode 15
A secret puts a strain on Jeff and Tamzin's friendship and makes life difficult for Dixie.
Episode 16
Tensions once again rise between Tom and Dominic as they argue over the treatment of a baby with severe hypothermia, and Dylan finally admits that he has not moved on from Sam.
Episode 17
Four student nurses receive a baptism of fire on their first shift in the ED.
Episode 18
Zoe is concerned that Jordan is not facing up to the severity of Yvonne's condition.
Episode 19
Jordan fights to keep his girlfriend's life support machine switched on but when an ill young woman arrives in the ED, he's forced to reconsider his motives.
Episode 20
It is the day of Yvonne Rippon's funeral, and Nylon gets Jordan to visit him.
Episode 21
Jordan is called on to save the life of the person who killed his girlfriend.
Episode 22
New doctor Ash hits the ground running when he treats a patient with suspected rabies, and Aoife is forced to take control when ex-boyfriend Craig arrives in Holby.
Episode 23
David tracks down his estranged wife, Kate, to get her help in saving their 10-year-old son who is dying of leukaemia. Meanwhile, Zoe has had to go home sick, leaving Ash to deal with the continuing flu epidemic.
Episode 24
Jeff must persuade David to act in his son's best interests, Fletch is determined to help an elderly man in love, and Zoe returns from sick leave and clashes with Ash.
Episode 25
Big Mac thinks he may have finally found the woman of his dreams but when she mistakes him for a doctor he doesn't set her straight. Ash clashes with Zoe when he carries out a risky procedure without telling her.
Episode 26
Ash and Zoe struggle to make a teenage boy accept the severity of his father's condition, while Linda helps a pregnant woman cope with her waster boyfriend.
Episode 27
Jeff is caught up in a marital dispute, and Robyn breaches patient confidentiality.
Episode 28
Robyn has to try and save her friend's life when a day at the fairground goes badly wrong.
Episode 29
Tom helps a young man with a troubled home life. Jamie treats a young boxer.
Episode 30
Zoe and Ash must work together to reunite two schoolgirls injured during a science exam.
Episode 31
Zoe goes out of her way to help and protect a young girl who she believes is at risk of female genital mutilation. Fletch deals with a man who needs to take responsibility for his health and lifestyle.
Episode 32
Jeff is distressed when his father and sister are involved in a car accident.
Episode 33
When hoodies raid an off-licence, a family must pull together to stop the gang's reign.
Episode 34
Ash deals with his daughter's admission to the ED after being hit by a drunken police driver, while Tom's judgement is called into question when a baby he has discharged nearly dies.
Episode 35
Linda's nursing experience enables her to see the bigger picture concerning a patient.
Episode 36
Tom is determined to show that a previous misdiagnosis isn't affecting his confidence.
Episode 37
When Tess witnesses a stabbing she becomes involved with the attacker and victim.
Episode 38
Lloyd tries to uncover the truth about a cannabis factory on his final day as a nurse.
Episode 39
Tom faces a dilemma of truth and confidentiality over the paternity of a baby.
Episode 40
Ash and Zoe have to protect a local shopkeeper who has been harassed by unruly kids.
Episode 41
Tom and Sam clash over the best course of action when a mother can no longer cope.
Episode 42
When Marcus is mugged, Sam and Fletch work together to reveal who the real victim is.
Episode 43
Tom is on a personal visit to a prison when unrest breaks out and trouble ensues.
Episode 44
Arthur and Chantelle struggle to cope in the aftermath of the mugging.
