Episode 1
Tom gets Spike sent to obedience school, and Jerry is left without a protector. When Spike returns, Tom tries hard to get Spike to revert to his old ways. Jerry fights back to make sure that Spike keeps his cool.
Episode 2
Tom is under strict orders to not wake the Witch sisters, but Jerry is set on getting Tom in trouble. When Tom uses the magic spell wand and makes all of the furniture come alive, he must get the help of Newt to make everything go back as it was.
Episode 3
Rick buys Ginger a brand new mattress with a lot of high tech features. Tom is under strict orders to never sleep on it, but Butch convinces him to try it out. Jerry uses the controls against them and soon that mattress is out of control and destroys the entire house.
Episode 4
Tom and Jerry get a taste of the great outdoors on their camping trip to Yosemite. Tom tries hard to relax, but nature - and all its inhabitants, including bears - get in his way.
Episode 5
When Tom and Jerry accidentally ruin Spike's birthday party for Tyke, he forces them to take over. They must entertain and take care of the puppy birthday bash, but no matter what they do, nothing seems to ever work out right.
Episode 6
When Toodles hires Tom and Jerry to investigate and protect her against a threat to her Tuna can inheritance. They go investigate, and a mysterious figure keeps trying to hurt them. They discover Butch was also hired by Toodles to protect the tuna. Spike was guarding the cans, but was distracted by the fighting and leaves the cans unprotected. They discover Toodles wasn't being completely honest with her story.
Episode 7
Tom and Jerry accidentally get locked out in the snow. They chase each other in the winter wonderland, until they realize they can't get back in. They work together to get back indoors as the weather turns ugly.
Episode 8
Jerry causes Tom to lose 8 out of his 9 lives. Tom uses magic to bring them back, and instead is stuck with 8 annoying ghost versions of himself. They try to catch Jerry, who is still too clever for them. Tom decides to work with Jerry and they come up with a magic spell to send these ghosts back where they came.
Episode 9
When Jerry ventures out of his hole for a late night snack, Tom has a trap set for him. Unfortunately for Tom, he falls into his own trap and gets his head stuck through the wall.
Episode 10
Detectives Tom and Jerry are hired by Polly the Dog to get back her collar from mean Barkley at the park. Later, Barkley reforms when he meets Polly and falls in love with her.
Episode 11
Little Quacker enlists Jerry's help to fix his favorite birdbath that has cracked, but the two get sidetracked by the scent of Tom's delicious Chinese takeout.
Episode 12
When Tom and Jerry fail to do things the right way, Spike must do everything he can to keep from losing his temper in front of Tyke.
Episode 13
Ginger is in charge of taking care of her mother's bird and Tom tries his hardest to keep from eating the bird.
Episode 14
Jerry pretends to be a vampire to scare Tom. Now it's up to Tom - with the help of his friend Newt - to defeat the vampire mouse!
Episode 15
When Rick leaves Spike in charge of protecting the house against burglars, Spike steps up and trains Tom and Jerry to be his helpers.
Episode 16
Tom is mistaken for Dr. Bigby's cat Wilson. Now Tom must convince Dr. Bigby he has the wrong cat! Meanwhile, Jerry and Napoleon are left with the real, very vicious Wilson.
Episode 17
Butch tricks Tom into switching places with him and sends Tom off to live the life of a street cat. But each finds the others life to be quite difficult.
Episode 18
Tuffy hires detectives Tom and Jerry to investigate the ghost hauntings in his house.
Episode 19
When it seems like Spike has developed an allergic reaction to Tom, Rick buys Ginger a hypoallergetic cat named Glory. Could Glory be too good to be true?
Episode 20
Dr. Bigby creates cookies that can give animals superpowers. Jerry and Napoleon sneak some cookies and have fun terrorizing Tom… until the tables are turned.
Episode 21
After a particularly destructive chase, Tom and Spike have to go to the vet and Ginger hires an exterminator to take care of Jerry and Tuffy once and for all.
Episode 22
Tom and Jerry have to go retrieve an ingredient for the witches' spell before sundown, but when Tom sees Princess Toodles, he quickly forgets the mission.
Episode 23
Tom kicks Spike's beloved chew toy Ruggles over the fence and has to get it back when he sees how heartbroken Spike becomes.
Episode 24
Butch and a squirrel detective steal all of Tom and Jerry's customers by using high-tech devices to solve crimes. Tom and Jerry challenges them to a case-solving competition.
Episode 25
When Rick and Ginger leave Tom home alone, Tom and Jerry decide to invite their lady friends over for a romantic dinner. But things don't go as planned.
Episode 26
Jerry gets affected by one of Dr. Bigby's experiments.
Episode 27
Butch locks Tom in the basement to keep him from a date with Toodles. Tom tries to escape, but keeps getting blocked by Jerry and Tuffy who think it's a monster downstairs.
Episode 28
Tom accidentally puts a spell on Santa and, as a result of Santa's new state, Tom and Jerry volunteer to help Santa deliver gifts. A Christmas miracle occurs.
Episode 29
Jerry and Tuffy are getting ready to go to a family reunion, but unfortunately, Tuffy gets left behind. Tom thinks Tuffy is easy pickings, but he's in for a surprise.
Episode 30
Tom and Jerry are hired by a bad magician to find out where his pigeon disappeared to during a magic trick gone awry.
Episode 31
When Tom and Butch compete to be top cat in the United Mouse Catchers, they must prove their worth by finally catching Jerry.
Episode 32
Hildie and Beatie commemorate the passing of their mother and Tom tries to help out by bringing her back from the grave.
Episode 33
Tom stars in a documentary that mis-characterizes his daily activities. All of his daily activities, from chasing Jerry to "romancing" Toodles are recorded.
Episode 34
Dr. Bigby invents a transporting machine that accidentally transports Jerry and Tom to Paris where they meet Gigi and Cozette.
Episode 35
Rick and Ginger go on a vacation and bring Tom and Spike aboard the plane. Stowaways Jerry and Tuffy are also on board, and soon the pets are chasing each other on the plane!
Episode 36
When Rick and Ginger sneak Tom and Spike into a hotel where pets are not allowed, they make the pets promise not to leave the hotel room. Will the pets behave?
Episode 37
On a cruise ship with Rick and Ginger, Jerry and Tuffy leave Spike and Tom in the room to go explore, but a vicious ship cat named Meathead will stop at nothing to terrorize them.
Episode 38
Rick and Ginger take Tom and Spike on a road trip where Spike is terrorized by a dog traveling in a trailer. Jerry and Tuffy get caught in Rick and Ginger's suitcase.
Episode 39
Hildie and Beatie bring home a fortune-telling magic mirror. When it shows Tom a future he doesn't like, he tries everything to avoid it - but this seems to make things worse.
Episode 40
Spike comes to Tom and Jerry for help finding his missing bones and the detectives investigate a community garden.
Episode 41
Dr. Bigby upgrades Bot to a Bot-y Guard. When Tom sets off Bot's defensive systems, things get out of control and Jerry and Napoleon must disarm Bot without hurting him.
Episode 42
When the witches' herb garden is destroyed, Tom sets a trap to capture the pest responsible. Quackers helps him but is unknowingly the pest Tom seeks to capture.
Episode 43
When Tom and Jerry lose Ginger's wedding ring down the drain, they send Jerry through the pipes to retrieve it, but it leads down the drain, to the sewers and out to the beach!
Episode 44
Dr. Bigby creates a helmet that turns Tom into a genius. Napoleon, Jerry and Hamster work together to take down the newly smart Tom who is now building a mouse-destroying weapon.
Episode 45
Tom witnesses what seems like the kidnapping of Misty, the cute cat across the street. He enlists the help of her neighbor to track down her whereabouts.
Episode 46
Fed up with Tom, Hildie and Beatie threaten to get a "real" witch's cat: a black cat. In desperation, Tom takes a magic potion that makes him turn black but only temporarily.
Episode 47
Believing they are going to run out of food during a snowstorm, the pets start hoarding food. Things get out of control when they start stealing food and double-crossing one other.
Episode 48
Jerry and Napoleon play around with Bigby's brand-new anti- gravity machine... until Tom breaks into the lab and a chase begins.
Episode 49
When the witches leave on vacation, Tom's dreams of rest and relaxation are ruined when their ghost nephew Grayson comes over and throws a giant ghost party.
Episode 50
Tom accidentally gives himself electrical superpowers, and now Jerry must fend off Tom while fighting off an asteroid heading right toward Bigby's lab.
Episode 51
Tom and Jerry are hired by Dutch to find a cursed ruby that causes him to have bad luck when it is missing.
Episode 52
Tom eats some canned cheese that has gone bad and hallucinates. Tom must become a better cat to end the nightmare.