Episode 1
The Henderson family returning from vacation accidentally hits an eight foot Bigfoot and brings it home. They decide to nurse him, and end up letting him stay with them.
Episode 2
Harry's need for attention takes its toll on the Hendersons, especially George, who bigfoot-sits while preparing a work assignment.
Episode 3
Harry feels uncomfortable in the Henderson home so he decides to run away.
Episode 4
The family takes Harry back to the woods, only to discover that his home territory has been clearcut. Meanwhile, Ernie doesn't want Harry to go away. (Part 1 of 2)
Episode 5
A local congressman's (Steve Landesberg) aid is sought when Harry's (Kevin Peter Hall) habitat is found destroyed. The clan petitions to save the forest. (Part 2 of 2)
Episode 6
George's and Ernie's attitudes differ over a father-son baseball game. George recruits Ken Griffey Jr. in a plan to spark Ernie's interest in baseball. Guest Stars: Ken Griffey Sr., Ken Griffey Jr.
Episode 7
A British explorer, the son of a famous hunter, wants to outshine his father. In order to do that, he plans to bag Harry.
Episode 8
The Hendersons try to close down an animal research lab by protesting after finding an escapee, a scruffy dog, on their doorstep.
Episode 9
Harry and an American Indian medicine man try to cure George's knee but he is reckless.
Episode 10
The only doctor who can help a dying Harry is an elderly embittered anthropologist whose theories about Bigfoot were stamped out.
Episode 11
A bully (Aeryk Egan) steals Ernie's special pair of sneakers needed by George for a presentation. Ernie uses Harry's formidable size and strength in a plan to retrieve them.
Episode 12
Harry befriends a homeless intruder who reveals that he built the Hendersons' house. Meanwhile, the Hendersons are celebrating a birthday.
Episode 13
A football legend visits the Hendersons' house along with his wife who is wearing a fur. Harry thinks that the fur is a dead person and decides to bury it.
Episode 14
When Harry hides Nancy's diamond ring, the Hendersons ask a pet psychic (Michael Winslow) to read Harry's mind.
Episode 15
A monster-movie director (Pat Morita) wants permission from the Hendersons to use Harry in one of his films.
Episode 16
Harry becomes a wrestler to help Sarah raise money to save an injured sea lion. George asks wrestler 'Hacksaw' Jim Duggan to judge a benefit match featuring the debut of reluctant wrestler 'Bigfoot Man'.
Episode 17
When Tiffany brings Harry home, George and Nancy tell Samantha the truth, whetting her appetite for a good news story. Samantha decides to break the story of Harry on her news program.
Episode 18
When three Dallas Cowboy cheerleaders come to town on a mascot search, Ernie dreams that he loses his pal Harry to stardom. Ernie fears Harry may become the new mascot for the Dallas Cowboys cheerleaders.